British Scientists find New Cancer killing Technique

The ultimate goal is to cure cancer effectively and painlessly. But in order to achieve it, scientists have to work not only on therapies themselves, but also on methods to develop and test them. Well but as of now, we have good news for you all and especially for people fighting with deadly disease – Cancer. The British Scientists find New Cancer killing Technique.

Some key facts about Cancer are:

1) Cancers figure among the leading causes of morbidity and mortality worldwide, with approximately 14 million new cases and 8.2 million cancer related deaths.

2) The number of new cases is expected to rise by about 70% over the next 2 decades.

3) Among men, the 5 most common sites of Cancer diagnosed were lung, prostate, colorectum, stomach, and liver cancer. Among women the 5 most common sites diagnosed were breast, colorectum, lung, cervix, and stomach cancer.

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However, Scientists of London, UK have finally come up with a new technique to combat with Cancer. The technique is called as ” Mito-priming” by whose means the tumor cells in our body will get addicted to the drugs that will eventually kill or eradicate them. This technique is being hailed all over the world and was actually invented in the process of research on the ”death of cancer cells”. Mito-priming was published in Nature communications.

Research paper says, BH3-mimetics are an effective need division of cancer medicine developed to supposedly kill tumour cells.

BH3-mimetic anticancer is showing good results in late stage clinical trials, especially in the treatment of chronic lymphocytic leukaemia (CLL).

Experts hope that this method can be applied to screen for new medicines to target BCL-2 proteins and eventually help find new ways to kill cancer cells, even benign ones.

Research paper’s lead author, Stephen trait said that “Finally, the technique will allow us to understand how drug resistance occurs thereby allowing us to prevent this from happening in the first place. There is currently a lot of interest in targeting BCL2 proteins in the fight against Cancer and there will be new therapies emerging in the future.”

According to him the cells at this very stage can be really sensitive to the inhibition of protective BCL-2 functions by BH3-mimetuics and hence can die within few minutes of addiction.

The technique was merely developed by producing equal amounts of toxic and protective BCL-2 proteins in cells.

These scientists are from Beatson Institute in Glasgow which is funded by cancer research UK and is closely associated with the Glasgow University.

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”Most apoptotic stimuli require Mitochondrial outer membrane permeabilization (MOMP) in order to execute cell death. As such, MOMP is subject to tight control by Bcl-2 family proteins. We have developed a powerful New Cancer killing Technique to investigate Bcl-2-mediated regulation of MOMP. This method, called Mito-priming, uses co-expression of pro- and anti-apoptotic Bcl-2 proteins to engineer Bcl-2 addiction. On addition of Bcl-2 targeting BH3 mimetic, mito-primed cells undergo apoptosis in a rapid and synchronous manner. Using this method we have comprehensively surveyed the efficacy of BH3 mimetic compounds, identifying potent and specific MCL-1 inhibitors. Furthermore, by combining different pro- and anti-apoptotic Bcl-2 pairings together with CRISPR/Cas9-based genome editing, we find that BID and PUMA can preferentially kill in BAK-dependent manner. In summary, mito-priming represents a facile and robust means to trigger mitochondrial apoptosis.”

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